As a weight loss expert, I have seen many patients struggle with finding the right medication to help them achieve their weight loss goals. With so many options on the market, it can be overwhelming to determine which prescription weight loss pill is the most successful. In this article, I will discuss the top medications approved by the FDA for chronic weight control and their effectiveness in helping patients lose weight and maintain a healthy lifestyle. One of the oldest and most commonly used weight-loss medications is phentermine. Originally used for short-term use, it has now been added to long-term therapy guidelines.
Studies have shown that patients can lose around 5% of their body weight by taking phentermine. The newest prescription drugs approved for obesity treatment are semaglutide (Wegovy) and tirzepatide (Zepbound). Other older medications include liraglutide (Saxenda), naltrexone-bupropion (Contrave), orlistat (Alli, Xenical), and phentermine-topiramate (Qsymia). While orlistat is designed for short-term use, it has been shown to help people achieve mild weight loss. Orlistat is also available in a lower dose over-the-counter option known as Alli. The FDA has approved six prescription medications for long-term use: orlistat (Xenical, Alli), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound).
Four of these drugs are approved for adults and children ages 12 or older. Another approved medication, setmelanotide (IMCIVREE), is limited to individuals diagnosed with one of four specific rare genetic disorders, confirmed by genetic testing. These medications can be taken as long as they are beneficial and do not cause serious side effects. Currently, GLP-1 agonists are considered the most effective anti-obesity medications and are safe for long-term use. However, only liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound) are approved for weight loss, although some other GLP-1 medications may be prescribed off-label. The FDA has approved several medications for weight loss in overweight and obese individuals.
One of these medications is semaglutide, which is given as an injection and approved for use in adults and children 12 years of age and older who are obese or overweight with weight-related medical problems. While it is not approved for obesity treatment, during trials for diabetes, researchers found that individuals taking tirzepatide lost significantly more weight than those receiving standard diabetes treatment. Many people struggle with losing weight in specific areas, such as the face. Losing fat in the face can change the shape of features and make the eyes and cheeks appear sunken. Individuals with a body mass index (BMI) of 30 or more or a BMI of 27 or more with weight-related health problems may be eligible for prescription weight loss medication.
Studies have shown that tirzepatide remains the top choice when looking at its effect on weight loss in individuals with type 2 diabetes. Participating in clinical trials can also provide early access to innovative treatments for weight loss. By participating, you can help doctors learn more about effective ways to lose weight and maintain a healthy lifestyle. As obesity is a chronic condition, it may require maintaining new eating habits, physical activity, and other behaviors for years or even a lifetime to improve overall health and maintain a healthy weight. Before considering a prescription weight loss medication, it is essential to consult with a healthcare professional. They can advise you on whether you are a candidate based on your personal goals, medical history, and health condition.
Phentermine works by reducing appetite, while topiramate helps individuals feel full, makes food less appealing, and burns more calories. In a 17-month study specifically looking at its effect on obesity, individuals taking the highest dose of tirzepatide lost an average of over 20% of their body weight. It is crucial to contact a trusted health professional, such as your obstetrician and gynecologist, before taking any weight-loss medication or supplement. If you do not lose 5% of your weight after 12 weeks of taking Contrave, your doctor may advise you to stop taking it as it is unlikely to work for you. Researchers continue to work towards identifying safer and more effective medications to help individuals who are overweight or obese lose weight and maintain a healthy lifestyle.
While studies have evaluated drugs that act on metabolic tissues, such as adipose tissue or muscle, to promote weight loss, they have not yet been brought into clinical practice. If you are not achieving a weight loss of more than 5% after 12 weeks of the maximum dose, it is recommended to gradually discontinue the diet pill. As an expert in the field of weight loss, I highly recommend consulting with a healthcare professional before starting any prescription medication for weight loss. With the right medication and lifestyle changes, achieving and maintaining a healthy weight is possible.
